MCM8- AND MCM9 DEFICIENCIES CAUSE LIFELONG INCREASED HEMATOPOIETIC DNA DAMAGE DRIVING P53-DEPENDENT MYELOID TUMORS

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Summary: Hematopoiesis is particularly sensitive to DNA damage.Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy.It is not known why hematopoietic cells are highly vulnerable to DNA damage.Addressing this question is complicated by the paucity of mouse models of hematopoietic malignancies due to defective

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Marginal/peripheral populations of forest tree species and their conservation status: report for Atlantic region

This report is a synthesis of information from the national reports, prepared as part of the COST Action FP1202 Strengthening conservation: a key issue for adaptation of marginal/peripheral populations of forest trees to climate change in Europe (MaPFGR).The individual national reports can be found as part of the supplemental data to the COST actio

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Transcriptomic and functional analyses reveal an antiviral role of autophagy during pepper mild mottle virus infection

Abstract Background Pepper mild mottle virus (PMMoV) is a member in the genus Tobamovirus and infects mainly solanaceous plants.However, the mechanism of virus-host interactions remains unclear.To explore the responses of pepper plants to PMMoV infection, we analyzed the transcriptomic changes in pepper plants after PMMoV infection using a high-thr

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Detection of Gray Mold Leaf Infections Prior to Visual Symptom Appearance Using a Five-Band Multispectral Sensor

Fungal leaf diseases cause economically important damage to crop plants.Protective treatments help producers to secure good quality crops.In contrast, curative treatments based on visually detectable symptoms are often riskier and less effective because COCONUT diseased crop plants may develop disease symptoms too late for curative treatments.There

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